Nih nocturnal leg cramps treatment1/20/2024 The recruitment was prospectively made by GPs using a systematic step of 1 in 4 attending patients aged 60 years or older. We generated the pools of cases and controls during the consultation time. The age limit of 60 was fixed based on the increased prevalence demonstrated in this age group 10. Patients were required to be 60 years old or older, autonomous in going about their daily life and consulting their general practitioner (GP) spontaneously for any reason. Study population and case control matching To the best of our knowledge, no study confirmed such a link, our aim was therefore to assess the association between a sedentary lifestyle and Nocturnal Leg Cramps in elderly patients. We hypothesize that there may be an association between sedentary lifestyle and NLC. Congruently with this assumption, musculoskeletal conditions associated with sedentary lifestyle 17 as well as work postures 18– 20, prolonged standing 21 and western habit of sitting instead of squatting 22 have been suspected of causing cramps and specifically NLC. Some authors suggest that neuromuscular structures located in muscle, tendons and nerve fibres seem to be involved in the trigger of muscle cramps 4– 6. Still, most cramps are considered idiopathic 16 and their physiological mechanism remains unclear 10, 14. Recently, we also showed a strong association with the global consumption of alcoholic beverages 15. Specific medical conditions and drug treatments have been identified to be associated with muscle cramps 10, 14. One of the reasons may be the known lack of both effective and safe treatments 9, 11– 13. Nonetheless, patients rarely report NLC to their general practitioners 4, 10, 11. Among patients over 60 years old the cramp prevalence varies from 46% to 56% 4, 9. NLC are associated with a reduced quality of sleep 6 and reduced physical component scores on the SF36 quality of life questionnaire 8. NLC is a specific entity of idiopathic cramps occurring at rest in the lower limb during the night 4– 7. Nocturnal Leg Cramps (NLC) are painful, involuntary contractions of muscles 1– 3. They also highlight the need to develop and evaluate physical activity interventions in the treatment of Nocturnal Legs Cramps. Our findings represent an additional argument to promote physical activity to patients over 60 years old. Adjusting for alcohol consumption, we observed an association between Nocturnal Leg Cramps and a sedentary lifestyle OR = 9.84 (95% credibility interval posterior probability 99.68%). 272 participants were matched into 136 pairs. We performed univariate and multivariate analyses adjusting for alcohol consumption. The level of physical activity was assessed using the Dijon Physical Activity Score (DPAS). Cases were matched with controls free from cramps for age, sex, medical history and medications known to trigger cramps. Patients over 60 years old consulting their family doctor were recruited in the Alsace region, France. A case-control study was conducted with a Bayesian approach for sensitivity analysis. This study aimed to explore the association between nocturnal leg cramps and a sedentary lifestyle among elderly patients. Lifestyle factors such as alcohol consumption have been shown to be associated with Nocturnal Leg Cramps. Nocturnal Legs Cramps are a frequent disorder, which have a negative impact on quality of life, particularly among patients over 60 years old.
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